Rocuronium-induced Neuromuscular Block after Long Pretreatment of Magnesium Sulfate in Rabbits / 대한마취과학회지
Korean Journal of Anesthesiology
; : 443-448, 2007.
Article
in Ko
| WPRIM
| ID: wpr-161787
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Magnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. This study was been conducted to evaluate the potency and time course of rocuronium-induced neuromuscular block after prolonged pretreatment with MgSO4 in rabbits. METHODS: Forty rabbits were randomly assigned to two groups; the control group: normal saline 0.1 ml/kg sq for 6 weeks; and the study group: 50% MgSO4 60 mg/kg sq for 6 weeks. The dose-response relationships of rocuronium were studied during thiopental anesthesia in twenty rabbits. Each group received rocuronium 40, 60 and 80microgram/kg rocuronium, respectively, and the time course of rocuronium, at 0.6 mg/kg, evaluated in the twenty rabbits in each group. RESULTS: The mean serum magnesium concentration were 2.3-2.6 and 3.3-3.9 mEq/L in the control and study groups, respectively (P < 0.001). The calculated ED50s for rocuronium were 52.7 and 61.2microgram/kg in the control and study groups, respectively (P < 0.05). The times after rocuronium administration until the 95% twitch recovery were 49.3 and 34.8 min in the control and study groups, respectively (P < 0.05). CONCLUSIONS: Rocuronium, following prolonged MgSO4 pretreatment had a decreased effect and short duration of action compared with the control, for which increased doses of nondepolarizing muscle relaxants would be required to obtain a similar effect.
Key words
Full text:
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Index:
WPRIM
Main subject:
Arrhythmias, Cardiac
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Pre-Eclampsia
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Thiopental
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Neuromuscular Blockade
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Hypertension
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Anesthesia
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Magnesium
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Magnesium Sulfate
Limits:
Animals
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article