The Erythrocyte 2,3-diphosphoglycerate Concentration and Its Related Factors in Patients with End-stage Liver Disease / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 430-437, 2007.
Article
in Korean
| WPRIM
| ID: wpr-161789
ABSTRACT
BACKGROUND:
It is believed that an increase in the level of erythrocyte 2,3-diphosphoglycerate is an important compensatory mechanism that allows satisfactory tissue oxygenation in hypoxic patients. This study measured the level of 2,3-diphophoglycerate and the factors affecting its concentration, as well as the position of the oxygen-hemoglobin dissociation curve in patients with end-stage liver disease.METHODS:
Fifty patients receiving liver transplantation (experimental group) and forty-five healthy donors (control group) were enrolled in this study. Arterial-mixed venous oxygen content difference, whole body oxygen delivery and consumption were measured after determining the hemodynamic parameters including cardiac output in the experimental group. The erythrocyte 2,3-diphosphoglycerate level was measured using assay procedures. The P50 value was used to determine the position of the oxygen-hemoglobin dissociation curve.RESULTS:
The 2,3-diphosphoglycerate level was higher in patients with end-stage liver disease than in the controls. A 0.3 g/L increase in the 2,3-diphosphoglycerate concentration corresponded to a P50 increase in 1.2 mmHg with a rightward displacement of the oxygen-hemoglobin dissociation curve. The 2,3-diphosphoglycerate concentration showed a significant correlation with the PaO2, Ca-vO2, P50, and blood lactate level, but not with the hemodynamic parameters such as the cardiac index, oxygen delivery index, and pH.CONCLUSIONS:
End-stage liver disease is associated with an increase in the level of the erythrocyte 2,3-diphosphoglycerate and P50. This is believed to be an important compensatory mechanism to allow better tissue oxygenation. An increase in the 2,3-diphosphoglycerate level correlates well with the oxygenation parameters, rather than with the hemodynamic parameters.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Tissue Donors
/
Cardiac Output
/
Liver Transplantation
/
Lactic Acid
/
2,3-Diphosphoglycerate
/
Erythrocytes
/
Hemodynamics
/
Hydrogen-Ion Concentration
/
Liver
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article
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