Association of Homocysteine Levels with Subclinical Coronary Atherosclerosis in Asymptomatic Subjects
Laboratory Medicine Online
;
: 221-227, 2016.
Article
in Korean
| WPRIM
| ID: wpr-161818
ABSTRACT
BACKGROUND:
Progression of atherosclerotic plaques is known to be correlated with elevated circulating homocysteine (Hcy). However, whether the level of Hcy is related with coronary atherosclerosis in the subclinical state is unclear. Therefore, we performed this study to investigate the relationship between blood Hcy levels and subclinical atherosclerosis in asymptomatic self-referred subjects.METHODS:
We retrospectively enrolled 2,968 self-referred asymptomatic subjects (1,374 men, 1,594 women) who had undergone both coronary CT angiography (CCTA) and coronary artery calcium scoring. The relationships between atherosclerosis, Hcy, and other clinical factors were assessed.RESULTS:
Higher levels of Hcy were related with age, male gender, body mass index (BMI), waist circumference, blood pressure, high density lipoprotein (HDL), triglyceride, blood glucose, HbA1c, hsCRP, and coronary artery calcium score (CACS). Coronary plaque was more frequently found in higher Hcy quartile groups (21.3%, 28.8%, 34.4%, and 34.3%, P50%) was also more frequent in higher Hcy quartile groups (1.8%, 5.4%, 5.0%, and 6.6%, P400) than the first quartile group.CONCLUSIONS:
Blood Hcy levels were associated with an increased risk of the presence and extent of subclinical atherosclerosis in asymptomatic subjects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Blood Glucose
/
Coronary Artery Disease
/
Angiography
/
Body Mass Index
/
Logistic Models
/
Odds Ratio
/
Calcium
/
Retrospective Studies
/
Coronary Vessels
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Laboratory Medicine Online
Year:
2016
Type:
Article
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