Your browser doesn't support javascript.
loading
Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis
Journal of Neurogastroenterology and Motility ; : 86-93, 2016.
Article in English | WPRIM | ID: wpr-162049
ABSTRACT
BACKGROUND/

AIMS:

Limited data exist on the outcome of gastroesophageal reflux disease (GERD) treatment and its impact on the health-related quality of life (HRQoL) in the Asian population. This study aims to evaluate the treatment outcomes, to investigate the factors associated with recurrence, and to evaluate the impact of the treatment outcome on the HRQoL in a Korean GERD population.

METHODS:

This was a prospective, multicenter study involving a total of 824 GERD patients. The response to treatment was assessed at week 4 (or week 8 for the patients who did not achieve complete resolution [CR] at week 4). The EQ-5D questionnaire was used at baseline, end of treatment, and first recurrence to assess the HRQoL. To assess GERD symptoms, contact of patients by phone at 1, 6, and 12 months following treatment was carried out.

RESULTS:

CR was achieved in 65.6% and recurrence was observed in 47.8% following treatment. CR and recurrence rates did not differ by the presence of esophagitis. Multivariate analysis revealed that acid regurgitation (odds ratio 2.249; 95% confidence interval 1.293-3.912; P = 0.004) and both acid regurgitation and heartburn (odds ratio 2.330; 95% confidence interval 1.392-3.901; P = 0.001) were independent risk factors for GERD recurrence. EQ-5D scores were more improved in patients with CR than in those without CR, and worsened more during follow-up in patients with recurrence than in those without recurrence.

CONCLUSIONS:

We should achieve complete symptom relief and attempt to prevent recurrence in GERD patients to improve their HRQoL.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Recurrence / Gastroesophageal Reflux / Multivariate Analysis / Prospective Studies / Risk Factors / Follow-Up Studies / Treatment Outcome / Asian People / Esophagitis Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Journal of Neurogastroenterology and Motility Year: 2016 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Recurrence / Gastroesophageal Reflux / Multivariate Analysis / Prospective Studies / Risk Factors / Follow-Up Studies / Treatment Outcome / Asian People / Esophagitis Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Journal of Neurogastroenterology and Motility Year: 2016 Type: Article