Risk Factors for Primary Multidrug Resistant Tuberculosis / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 600-605, 2005.
Article
in English
| WPRIM
| ID: wpr-162065
ABSTRACT
BACKGROUND:
Primary multidrug-resistant tuberculosis is defined as Mycobacterium tuberculosis isolates that are resistant to at least isoniazid and rifampin in never-been-treated tuberculosis patients, and this malady is caused by the transmission of a resistant strain from one patient, who is infected with a resistant Mycobacterium tuberculosis strain, to another patient. The prevalence of primary multidrug-resistant tuberculosis could be a good indicator of the performance of tuberculosis control programs in recent years. We conducted a case-control study to identify the risk factors for primary multidrug-resistant tuberculosis.METHODS:
From January 1, 2001 to, June 30, 2003, by conducting prospective laboratory-based surveillance, we identified 29 hospitalized patients with P-MDRTB and these patients constituted a case group in this study. The controls were represented by all the patients with culture-confirmed drug susceptible tuberculosis who were admitted to National Masan Hospital during the same study period. The odds ratios for the patients with primary multidrug-resistant tuberculosis, as compared with those of the patients with drug susceptible tuberculosis, were calculated for each categorical variable with 95% confidence intervals.RESULTS:
Multivariate logistic regression showed that the presence of diabetes mellitus (odds ratio 2.68; 95% confidence interval, 1.05-6.86) was independently associated with having primary multidrug-resistant tuberculosis.CONCLUSION:
This study has shown that diabetes mellitus might be one of the risk factors for primary multidrug-resistant tuberculosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rifampin
/
Tuberculosis
/
Drug Resistance
/
Case-Control Studies
/
Logistic Models
/
Odds Ratio
/
Prevalence
/
Prospective Studies
/
Risk Factors
/
Tuberculosis, Multidrug-Resistant
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2005
Type:
Article
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