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The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer's Disease
Clinical Psychopharmacology and Neuroscience ; : 168-173, 2015.
Article in English | WPRIM | ID: wpr-162185
ABSTRACT

OBJECTIVE:

We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.

METHODS:

Patients who met the criteria for probable Alzheimer's disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student's t-test.

RESULTS:

At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (p=0.02 for MMSE-KC and p=0.03 for CERAD-K(N) WSS respectively).

CONCLUSION:

Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Choline / Choline O-Acetyltransferase / Follow-Up Studies / Polymorphism, Single Nucleotide / Depression / Alleles / Alzheimer Disease / Genotype Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Clinical Psychopharmacology and Neuroscience Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Choline / Choline O-Acetyltransferase / Follow-Up Studies / Polymorphism, Single Nucleotide / Depression / Alleles / Alzheimer Disease / Genotype Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Clinical Psychopharmacology and Neuroscience Year: 2015 Type: Article