Concurrence of Membranous Glomerulonephritis and Pulmonary Alveolar Proteinosis / 대한내과학회지
Korean Journal of Medicine
;
: 215-218, 2014.
Article
in Korean
| WPRIM
| ID: wpr-162310
ABSTRACT
Membranous glomerulonephritis is one of the most common causes of nephrotic syndrome in adults. Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which abnormal accumulation of surfactant occurs within the alveoli. We describe a 61-year-old man with concurrent membranous glomerulonephritis and PAP, which is very rare; both are pathophysiologically related to an abnormal immune response. A patient came to hospital with leg edema but no respiratory symptoms. Chest X-ray and CT showed classical PAP findings, which are ground-glass opacities with interlobular septal thickening, in both lung fields. A bubbly whitish secretion retrieved via broncho-alveolar lavage showed neutrophils and lymphocytes as well as Periodic acid-Schiff-positive proteinaceous materials. A kidney biopsy revealed findings of membranous glomerulonephritis with irregular subepithelial deposits by electron microscopy. At 1 year after diagnosis, the membranous glomerulonephritis was well under control with steroids and mycophenolate mofetil but PAP became aggravated gradually and whole-lung lavage was needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Alveolar Proteinosis
/
Steroids
/
Thorax
/
Biopsy
/
Lymphocytes
/
Microscopy, Electron
/
Glomerulonephritis, Membranous
/
Diagnosis
/
Edema
/
Therapeutic Irrigation
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2014
Type:
Article
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