Retrospective Study on the Impact of Hepatitis B and Hepatitis C Virus Infection on Renal Transplnat Recipients Over 15 Years / 대한신장학회잡지
Korean Journal of Nephrology
;
: 423-434, 2002.
Article
in Korean
| WPRIM
| ID: wpr-162514
ABSTRACT
BACKGROUND:
The impact of hepatitis B or hepatitis C virus infection on renal transplantation outcome is controversial. The aim of this study is to assess the impact of hepatitis B and hepatitis C infection on kidney transplant over the long-term, 15 years and to compare infected patients with noninfected patients matched for factors possibly associated with graft and patient survival.METHODS:
We analyzed 1,042 patients who underwent renal transplantation in period from March 1984 to Dec. 1998 including 107 with positive HBsAg (HBV(+) group), 81 with positive anti-HCV antibody (HCV(+) group) and 714 noninfected recipients (NBNC group). One hundred-forty patients who had not taken ani-HCV antibody screening test were excluded. The prevalence of chronic liver disease, the patient mortality, the patient survival rate and the graft survival rate were evaluated.RESULTS:
The patient mortality during the period of follow-up was significantly higher in HBV(+) group(32.7%) than in HCV(+) group(9.9%) and NBNC group(8.4%). The cause of death related to liver desease was significantly higher in HBV(+) group(57.1%) than HCV(+) group(0%) and NBNC group(1.7%). Five year and 10 year graft survival rate were significantly lower in HBV(+) group(52.2 %, 39.2%) than in HCV(+) group(68.4%, 47.2%) and NBNC group(86.6%, 65.8%). Five year and 10 year patient survival rate of HBV(+) group(72.0%, 68.9%) was significantly lower than HCV(+) group(91.6%, 87.3%) and NBNC group(94.4%, 88.2%), but there was no significant difference in the patient survival rate between HCV(+) and NBNC group.CONCLUSION:
Hepatitis B virus infection has a significant deleterious effect on the patient and graft survival of renal transplantation recipients. The poor survival rate was a result of the mortality from liver disorder. Hepatitis C virus infection also has a poor graft survival rate compared to NBNC group, but the patient survial rate is similar to NBNC group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Hepatitis B virus
/
Mass Screening
/
Prevalence
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
/
Mortality
/
Cause of Death
/
Kidney Transplantation
/
Hepatitis C
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2002
Type:
Article
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