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Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
Journal of Korean Medical Science ; : 1708-1712, 2017.
Article in English | WPRIM | ID: wpr-16259
ABSTRACT
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA® XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stem Cells / Swine / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells / Cell- and Tissue-Based Therapy / Heart / Heart Failure / Korea / Myocardial Infarction Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stem Cells / Swine / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells / Cell- and Tissue-Based Therapy / Heart / Heart Failure / Korea / Myocardial Infarction Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2017 Type: Article