Effects of Nitric Oxide Synthase (NOS) Inhibitor on MIL801-elicited Behaviors in Rats / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 113-119, 2002.
Article
in Korean
| WPRIM
| ID: wpr-162863
ABSTRACT
OBJECTIVE:
The aim of the present study was to investigate the effects of nitric oxide synthase (NOS) inhibitor on MK-801-elicited behaviors in rats in an attempt to elucidate the participation of NO in the pathophysiology of schizophrenia and to identify the possibility of NOS inhibitor's antipsychotic property.METHODS:
Male Sprague-Dawley rats, weighing 250-300g, were given MK-801 in order to know behavioral changes induced by MK-801. Next time, animals were pretreated with Nomega-nitro-L-arginine (L-NA) as a NOS inhibitor and haloperidol before administration of MK-801, respectively. Separate behavioral rating scales were introduced for quantifying MK-801-induced locomotor activity, stereotyped behaviors and ataxia in order that these behaviors might be assessed independently. Animals were observed for 30 seconds and scored once every 10 min. during a period of 1 hour.RESULTS:
1) Locomotor activity and stereotyped behavior were significantly increased by MK-801 in rats. 2) Locomotor activity and stereotyped behavior were significantly diminished by pretreatment with haloperidol. 3) Locomotor activity and stereotyped behavior were also significantly diminished by pretreatment with L-NA.CONCLUSIONS:
These findings suggest that NO may, in part, mediate behavioral changes induced by MK-801, and that inhibitors of NOS may have antipsychotic action.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ataxia
/
Schizophrenia
/
Stereotyped Behavior
/
Weights and Measures
/
Dizocilpine Maleate
/
Rats, Sprague-Dawley
/
Nitric Oxide Synthase
/
Haloperidol
/
Motor Activity
/
Nitric Oxide
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2002
Type:
Article
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