Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus
Journal of Bacteriology and Virology
;
: 206-207, 2014.
Article
in Korean
| WPRIM
| ID: wpr-162996
ABSTRACT
Cyclic guanosine monophosphate adenosine monophosphate (cGAMP) synthase (cGAS) detects human immunodeficiency virus (HIV) and produces cGAMP to induce cytokines. Reverse transcribed DNA of HIV is critical for triggering innate immune responses as inhibitor of HIV reverse transcriptase blocked the induction of interferon-beta by the virus. Furthermore, knockout of cGAS in human or mouse cell lines abrogated the production of cytokines by HIV infection highlighting the essential role of cGAS in detection of HIV and other retroviruses.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retroviridae
/
DNA
/
HIV Infections
/
Cell Line
/
Adenosine Monophosphate
/
Cytokines
/
HIV
/
Interferon-beta
/
Guanosine Monophosphate
/
HIV Reverse Transcriptase
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS