A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid
Endocrinology and Metabolism
;
: 221-225, 2015.
Article
in English
| WPRIM
| ID: wpr-16308
ABSTRACT
Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves as a serum marker of MTCs. Here, the rare case of a calcitonin-negative neuroendocrine tumor (NET) derived from follicular lesions of the thyroid is described. A 34-year-old man presented at our hospital for the surgical management of an incidental thyroid nodule that was observed on an ultrasound sonography (USG) of the neck. Initially, USG-guided aspiration cytology was performed, and a MTC was suspected. The expressions of thyroglobulin and thyroid transcription factor-1, which are thyroid follicular cell markers, and synaptophysin and chromogranin A, which are neuroendocrine markers, was confirmed following surgical pathology. However, the staining of calcitonin, a marker of MTCs, was not observed. A nonmedullary NET of the thyroid is uncommon, and the distinction between calcitonin-negative NETs and MTCs of the thyroid may be important due to differences in their clinical courses and management.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology, Surgical
/
Thyroglobulin
/
Thyroid Gland
/
Calcitonin
/
Thyroid Neoplasms
/
Biomarkers
/
Ultrasonography
/
Thyroid Nodule
/
Synaptophysin
/
Neuroendocrine Tumors
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2015
Type:
Article
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