Influence of Age, Rate of Obesity, Hepatic Function and Renal Function on Serum Prostate-Specific Antigen in Men Older than 50 Years / 대한비뇨기과학회지
Korean Journal of Urology
;
: 1284-1290, 2001.
Article
in Korean
| WPRIM
| ID: wpr-163084
ABSTRACT
PURPOSE:
We investigated the influence of age, rate of obesity, hepatic function and renal function on serum prostate-specific antigen in healthy men older than 50 years. MATERIALS ANDMETHODS:
From January 1999 to December 2000, 2,296 healthy Korean men older than 50 years who visited Health Promotion Center at our hospital for a routine health checkup were entered into a prospective study. All men underwent detailed clinical examinations, including serum prostate-specific antigen (PSA) determination using Hybritech Tandem-R assay, anthropometric measurements, tests for liver disease, tests for renal function, and other constitutes. We determined the risk factors of the increase of serum PSA among these clinical parameters using univariate and multivariate logistic regression analyses.RESULTS:
The univariate logistic regression analysis indicated that age, alanine aminotransferase (ALT), hemoglobin, potassium, albumin, high-density lipoprotein (HDL) were the risk factors of the increase of serum PSA. In the multivariate model used, age, ALT, alkaline phosphatase, albumin, HDL and cholesterol were an independent predictors of the increase of serum PSA, whereas hemoglobin and potassium lost their statistical significance.CONCLUSIONS:
Our findings suggest that the health status as well as may influence on serum PSA level of healthy men older than 50 years. Additional work is needed to determine and validate the clinical significance of these findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Potassium
/
Logistic Models
/
Cholesterol
/
Prospective Studies
/
Risk Factors
/
Prostate-Specific Antigen
/
Alanine Transaminase
/
Alkaline Phosphatase
/
Health Promotion
/
Lipoproteins
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2001
Type:
Article
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