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Long-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma
Gut and Liver ; : 318-323, 2014.
Article in English | WPRIM | ID: wpr-163234
ABSTRACT
BACKGROUND/

AIMS:

Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more effective than PDT alone.

METHODS:

In total, 161 patients with cholangiocarcinoma diagnosed between February 1999 and September 2009 were evaluated. Sixteen patients were treated with PDT and chemotherapy (group A), and 58 were treated with PDT (group B).

RESULTS:

The median survival was 538 days (95% confidence interval [CI], 475.3 to 600.7) in group A and 334 days (95% CI, 252.5 to 415.5) in group B (p=0.05). Lymph node metastasis status, serum bilirubin of pretreatment, tumor node metastasis stage, treatment method (PDT with chemotherapy vs PDT alone), time to PDT and the number of PDT sessions were prognostic factors with statistical significance in the univariate analysis. A multivariate analysis showed that PDT with chemotherapy and more than two sessions of PDT were significant independent predictors of longer survival in advanced cholangiocarcinoma (hazard ratio [HR], 2.23; 95% CI, 1.18 to 4.20; p=0.013 vs HR, 1.79; 95% CI, 1.044 to 3.083; p=0.034).

CONCLUSIONS:

PDT with chemotherapy results in longer survival than PDT alone.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Photochemotherapy / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Antineoplastic Combined Chemotherapy Protocols / Cholangiopancreatography, Endoscopic Retrograde / Cisplatin / Treatment Outcome / Cholangiocarcinoma / Combined Modality Therapy / Deoxycytidine Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Photochemotherapy / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Antineoplastic Combined Chemotherapy Protocols / Cholangiopancreatography, Endoscopic Retrograde / Cisplatin / Treatment Outcome / Cholangiocarcinoma / Combined Modality Therapy / Deoxycytidine Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2014 Type: Article