Predictors of Poor Outcome in Patients with Acute Cerebral Infarction
Journal of Clinical Neurology
;
: 197-202, 2011.
Article
in English
| WPRIM
| ID: wpr-163267
ABSTRACT
BACKGROUND AND PURPOSE:
Plasma D-dimer levels are elevated during the acute phase of cerebral infarction (CI). We investigated whether the D-dimer level on admission and other clinical characteristics could be used to predict the poor outcome of patients with acute CI.METHODS:
The clinical characteristics and plasma D-dimer levels measured within 3 days of onset were compared according to outcome among patients with acute CI.RESULTS:
In total, 359 consecutive patients (mean age, 71.8 years) were examined, of which 174 had a poor outcome [score on the modified Rankin scale (mRS) > or =3] at 30 days after hospitalization. The mean mRS score was higher and a poor outcome was observed more frequently among women than among men (p or =75 years), prior history of CI or transient ischemic attack, and elevated D-dimer level (> or =1.0 microg/mL) were significantly higher among patients with a poor outcome than among those with a good outcome. A multivariate analysis showed that elevated D-dimer level [> or =1.0 microg/mL; odds ratio (OR), 2.45; 95% confidence interval (95% CI), 1.52-3.89; p<0.01], advanced age (OR, 1.93; 95% CI, 1.21-3.07; p<0.01), and female gender (OR, 1.75; 95% CI, 1.08-2.83; p=0.02) were independent predictors of a poor outcome.CONCLUSIONS:
Certain clinical characteristics (gender and advanced age) and an elevated D-dimer level upon admission can be used to predict the outcome of patients with acute CI at 30 days after hospitalization.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Atrial Fibrillation
/
Fibrin Fibrinogen Degradation Products
/
Odds Ratio
/
Cerebral Infarction
/
Ischemic Attack, Transient
/
Multivariate Analysis
/
Stroke
/
Hospitalization
Type of study:
Etiology study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2011
Type:
Article
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