Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus
Annals of Pediatric Endocrinology & Metabolism
;
: 69-73, 2015.
Article
in English
| WPRIM
| ID: wpr-163415
ABSTRACT
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Axis, Cervical Vertebra
/
Insulin-Like Growth Factor I
/
Carrier Proteins
/
Glucose Intolerance
/
Insulin-Like Growth Factor Binding Proteins
/
Insulin-Like Growth Factor Binding Protein 1
/
Insulin-Like Growth Factor Binding Protein 3
/
Diabetes Mellitus
/
Diabetes Mellitus, Type 1
/
Lipid Metabolism
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2015
Type:
Article
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