Bilateral retinoblastoma: Long-term follow-up results from a single institution / 소아과
Korean Journal of Pediatrics
;
: 674-679, 2009.
Article
in English
| WPRIM
| ID: wpr-163695
ABSTRACT
PURPOSE:
The authors aimed to analyze the long-term effects of treatments, especially external beam radiotherapy (EBRT), in bilateral retinoblastoma patients.METHODS:
This retrospective study analyzed the medical records of 22 bilateral retinoblastoma patients who were registered between October, 1987 and October, 1998 and followed-up for more than 10 years. They were treated by enucleation, EBRT, and systemic chemotherapy. Age at diagnosis, sex, delay prior to treatment, Reese-Ellsworth (RE) classification, and the local treatment modalities were analyzed in relation to recurrence-free survival (RFS) and complications.RESULTS:
Median age at diagnosis was 7.0 months (range 1.7-31.6 months). Leukocoria was the most common presenting feature. Two patients had a familial history. The RE classifications of the 44 eyes were group II in 4, III in 14, IV in 4, and V in 22. At the end of a median follow-up period of 141 months (range 55-218 months), 20 patients were alive. The 10-year ocular survival rate of the 44 eyes was 56.8+/-7.5%. The 10-year RFS and ocular survival rate of the 29 eyes treated by combined EBRT and chemotherapy were 75.9% and 86.2%, respectively. Treatment delay (>3 months) was found to be related to higher risk of recurrence. Complications after EBRT were cataract, retinal detachment, phthisis bulbi, and facial asymmetry. No patient developed a second malignancy during the follow-up period.CONCLUSION:
Early detection and prompt treatment can increase ocular survival rates. In addition, careful attention should be paid to possible long-term sequelae in these patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Retinoblastoma
/
Cataract
/
Retinal Detachment
/
Medical Records
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
/
Neoplasms, Second Primary
/
Eye
Type of study:
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2009
Type:
Article
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