Effects of Methylprednisolone on the Neural Conduction of the Motor Evoked Potentials in Spinal Cord Injured Rats
Journal of Korean Medical Science
;
: 132-138, 2005.
Article
in English
| WPRIM
| ID: wpr-163763
ABSTRACT
Methylprednisolone (MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury (SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to salinetreated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Spinal Cord
/
Spinal Cord Injuries
/
Time Factors
/
Methylprednisolone
/
Sodium Chloride
/
Receptors, Glucocorticoid
/
Rats, Sprague-Dawley
/
Evoked Potentials, Motor
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2005
Type:
Article
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