Prognostic Significance of DNA Content and S-Phase Fraction in Gastric Carcinomas
Journal of the Korean Surgical Society
;
: 602-608, 2000.
Article
in Korean
| WPRIM
| ID: wpr-163785
ABSTRACT
PURPOSE:
DNA flow cytometry is a simple and easy method to assess the DNA content and the cell-cycle distribution of a tumor cell. The prognostic significance of the DNA content and the S-phase fraction in a gastric carcinoma has been controversial. The purpose of this study was to evaluate the prognostic significance of the nuclear DNA content and the S-phase fraction in patients with a gastric carcinoma.METHODS:
Between May 1995 and March 1996, 94 patients who were underwent a gastric resection for a gastric carcinoma were evaluated with DNA flow cytometry. Of them, 88 patients underwent a gastric resection with curative intent. The relationship of variable clinicopathological factors and of recurrence pattern to survival and nuclear DNA content were assessed.RESULTS:
The mean age was 55 years. 55 patients (58.5%) exbitied diploidy and 39 patients (41.5%) aneuploidy. There was no relationship between the clinicopathological factors and either the ploidy pattern or the S-phase fraction. Though the recurrence and its pattern were not different between the two ploidy group (p=0.860, 0.137), diploidy tended to recur locoregionally and aneuploidy hematogenously.CONCLUSION:
The ploidy pattern was a significant prognostic factor in gastric carcinomas, but should be interpreted carefully.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ploidies
/
Prognosis
/
Recurrence
/
DNA
/
Diploidy
/
Flow Cytometry
/
Aneuploidy
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2000
Type:
Article
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