A Pilot Study on Total Plasma Homocysteine Level of Patients with Cerebral Infarction
Journal of the Korean Neurological Association
;
: 26-31, 1999.
Article
in Korean
| WPRIM
| ID: wpr-163886
ABSTRACT
BACKGROUND:
Hyperhomocysteinemia has been known to be associated with cerebrovascular disease. It is toxic to vascular endothelial cell and promotes arteriosclerotic detachment. There was no study of the homocysteine level in ischemic stroke patients in Korea except case report. Therefore we measured total plasma homocysteine level in ischemic stroke patients and evaluated association with other stroke risk factors.METHODS:
We measured total plasma homocysteine level in 44 patients with ischemic stroke and 16 age-matched normal controls, and analyzed its relationship to other stroke risk factors. Total plasma homocysteine level was determined by using a radioenzymatic method.RESULTS:
Total plasma homocysteine level was 12.12 5.11 micromol/L in patients and 9.40 1.93 micromol/L in controls. It was 13.03 5.78 micromol/L in lacunar infarction and 9.96 1.57 micromol/L in territory infarction. The total plasma homocysteine level of the patients with hypertension, DM, hyperlipidemia, heart disease, smoking, alcohol, previous stroke, carotid bruit was not different statistically from those without them.CONCLUSIONS:
Total plasma homocysteine level was significantly higher in the ischemic stroke patients than that of controls. Lacunar infarction showed significantly higher level of total plasma homocysteine compared to territory infarction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Smoke
/
Smoking
/
Cerebral Infarction
/
Pilot Projects
/
Risk Factors
/
Hyperhomocysteinemia
/
Stroke
/
Endothelial Cells
/
Stroke, Lacunar
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
1999
Type:
Article
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