Can Fecal Calprotectin Level Be Used as a Markers of Inflammation in the Diagnosis and Follow-Up of Cow's Milk Protein Allergy?
Allergy, Asthma & Immunology Research
;
: 33-38, 2014.
Article
in English
| WPRIM
| ID: wpr-164123
ABSTRACT
PURPOSE:
Calprotectin is a cytosolic protein with immunomodulatory, antimicrobial, and antiproliferative actions. The concentration of calprotectin increases in infection, inflammation, and malignancy. We determined if calprotectin can be used as a marker for the diagnosis and follow-up of bowel inflammation in cow's milk protein allergy (CMPA).METHODS:
In total, 32 patients newly diagnosed with CMPA were included (24 IgE-mediated, 8 non-IgE-mediated). In all subjects, a complete blood count, total IgE, cow's milk-specific IgE, and fecal calprotectin (FC) were assessed before and after a cow's milk protein (CMP) elimination diet was started. The results were compared with those of 39 healthy children.RESULTS:
The mean FC value before the CMP elimination diet was 516+/-311 microg/g in the 32 patients with CMPA and 296+/-94 microg/g in the control group (P=0.011). The mean FC value after the diet in these patients was 254+/-169 microg/g, which was significantly different from the mean value before the CMP elimination diet (P<0.001). When we compared FC levels before the CMP elimination diet in the IgE-mediated group with the control group, we found no significant statistical difference (P=0.142). The mean FC value before the CMP elimination diet was 886+/-278 microg/g in the non-IgE-mediated group and 296+/-94 microg/g in the control group; this difference was statistically significant (P<0.001). In the IgE-mediated and non-IgE-mediated groups, FC values after CMP elimination diet were 218+/-90 microg/g and 359+/-288 microg/g, respectively, and FC values before CMP elimination diet were 392+/-209 microg/g and 886+/-278 microg/g, respectively; these differences were statistically significant (P=0.001 and P=0.025, respectively).CONCLUSIONS:
FC levels may be a useful marker for follow-up treatment and recurrence determination in CMPA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Blood Cell Count
/
Immunoglobulin E
/
Follow-Up Studies
/
Milk Hypersensitivity
/
Cytosol
/
Leukocyte L1 Antigen Complex
/
Milk
/
Diagnosis
/
Diet
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2014
Type:
Article
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