Expression of Major Gangliosides in Normal and Alzheimer Disease Brain
Korean Journal of Pathology
;
: 400-405, 2002.
Article
in Korean
| WPRIM
| ID: wpr-164137
ABSTRACT
BACKGROUND:
GM1 ganglioside-bound amyloid beta-protein (GM1/A) has been reported to be involved with senile plaque formation in Alzheimer disease.METHODS:
To investigate the binding of major gangliosides on senile plaques and neurofibrillary tangles of Alzheimer disease-specific pathology, we developed four monoclonal antibodies -- GM1, GD1a, GD1b, and GT1b -- employing the hydridoma technique, and applied them for immunohistochemical staining at the frontotemporal neocortex and hippocampus of Alzheimer disease brains and age-matched control brains.RESULTS:
Moderate immunopositivity for GM1 and GD1a was noted on the senile plaques and neurofibrillary tangles. Mild immunopositivity for GD1b and GT1b on neurofibrillary tangles was noted. Strong GD1b immunopositivity was observed on a few neurons and neurites. Strong immunopositivity for GT1b, and moderate immunopositivity for GM1 and GD1a were noted on reactive astrocytes.CONCLUSIONS:
These observations suggest that GM1 and GD1a may be involved in the formation of senile plaques as well as neurofibrillary tangles in Alzheimer disease brains.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Brain
/
Immunohistochemistry
/
Astrocytes
/
Amyloid beta-Peptides
/
Neurofibrillary Tangles
/
Neurites
/
Neocortex
/
Plaque, Amyloid
/
Alzheimer Disease
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS