The Expression of Death Domain Receptor-3, Caspase-10, Insulin-Like Growth Factor Binding Protein-3 in the Placentas of Preeclampsia / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 399-405, 2002.
Article
in Korean
| WPRIM
| ID: wpr-164147
ABSTRACT
OBJECTIVE:
To determine that preeclampsia is associated with differential expression of death domain receptor-3(DDR-3), caspase-10, and insulin-like growth factor binding protein-3(IGFBP-3).METHODS:
Placenta were collected from 10 preeclampsias and from 15 normal pregnancies and the samples were immediately frozen and stored at -70degrees C. Total mRNA was extracted from placental tissue and then analysis of the expressions of DDR-3, caspase-10, and IGFBP-3 were performed by quantitative RT-PCR.RESULTS:
Quantitative RT-PCR analysis demonstrated significantly increased DDR-3 and caspase-10 expression levels and significantly decreased IGFBP-3 expression level in the placenta of preeclampsia compared with normal pregnancy.CONCLUSION:
Placental apoptosis is associated with DDR-3, caspase-10, and IGFBP-3. These results may be one of possible mechanisms in the placental apoptosis of preeclampsia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Pre-Eclampsia
/
RNA, Messenger
/
Apoptosis
/
Insulin-Like Growth Factor Binding Protein 3
/
Caspase 10
Limits:
Pregnancy
Language:
Korean
Journal:
Korean Journal of Perinatology
Year:
2002
Type:
Article
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