Decreased Expression of α-Synuclein, Nogo-A and UCH-L1 in Patients with Schizophrenia: A Preliminary Serum Study
Psychiatry Investigation
;
: 344-349, 2017.
Article
in English
| WPRIM
| ID: wpr-164257
ABSTRACT
OBJECTIVE:
α-synuclein, Nogo-A and Ubiquitin C-terminal hydrolase L1 (UCH-L1) have neuromodulatory roles for human brain. Therefore, abnormalities of these molecules are associated with neuropsychiatric disorders. Although some serum studies in the other disorders have been made, serum study of α-synuclein, Nogo-A and UCH-L1 is not present in patients with schizophrenia and healthy controls. Therefore, our aim was to compare serum levels of α-synuclein, Nogo-A and UCH-L1 of the patients with schizophrenia and healthy controls.METHODS:
Forty-four patients with schizophrenia who is followed by psychotic disorders unit, and 40 healthy control were included in this study. Socio-demographic form and Positive and Negative Syndrome Scale (PANSS) was applied to patients, and sociodemographic form was applied to control group. Fasting bloods were collected and the serum levels of α-synuclein, Nogo-A and UCH-L1 were measured by ELISA method.RESULTS:
Serum α-synuclein [patient 12.73 (5.18–31.84) ng/mL; control 41.77 (15.12–66.98) ng/mL], Nogo-A [patient 33.58 (3.09–77.26) ng/mL; control 286.05 (136.56–346.82) ng/mL] and UCH-L1 [patient 5.26 (1.64–10.87) ng/mL; control 20.48 (11.01–20.81) ng/mL] levels of the patients with schizophrenia were significianly lower than healthy controls (p<0.001).CONCLUSION:
Our study results added new evidence for explaining the etiopathogenesis of schizophrenia on the basis of neurochemical markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychotic Disorders
/
Schizophrenia
/
Brain
/
Enzyme-Linked Immunosorbent Assay
/
Biomarkers
/
Fasting
/
Ubiquitin Thiolesterase
/
Methods
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2017
Type:
Article
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