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Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C
Psychiatry Investigation ; : 314-324, 2017.
Article in English | WPRIM | ID: wpr-164260
ABSTRACT

OBJECTIVE:

The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and personality traits predicted the evolution of depression.

METHODS:

CHC patients without depression were screened with laboratory tests; psychiatric interviews; and evaluations of mood symptoms, level of distress, and personality traits. A total of 67 treatment-naïve patients with CHC were consecutively treated with PEG-IFN-α-2a plus ribavirin for 48 (genotype 1, n=29) or 24 (genotype 2, n=38) weeks. Patients were followed prospectively every 4 weeks during the treatment period.

RESULTS:

Seven patients (10.4%) were diagnosed with major depressive disorder (MDD), and eight (11.9%) developed subsyndromal depression. Times to onset of MDD and subsyndromal depression were 6.67±5.01 and 11.11±5.58 weeks, respectively, after initiation of treatment. Patients who developed MDD had significantly increased fatigue and anxiety and poor psychological well-being during the course of treatment. Pretreatment subthreshold mood symptoms were a significant predictor of depression.

CONCLUSION:

An early psychiatric assessment may be helpful in improving psychological well-being in those with CHC, leading to adherence to PEG-IFN-based treatment.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Anxiety / Ribavirin / Prospective Studies / Interferons / Hepatitis C / Hepatitis C, Chronic / Depression / Depressive Disorder, Major / Fatigue / Hepatitis Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Psychiatry Investigation Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Anxiety / Ribavirin / Prospective Studies / Interferons / Hepatitis C / Hepatitis C, Chronic / Depression / Depressive Disorder, Major / Fatigue / Hepatitis Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Psychiatry Investigation Year: 2017 Type: Article