Ascitic Fluid Calprotectin and Serum Procalcitonin as Accurate Diagnostic Markers for Spontaneous Bacterial Peritonitis
Gut and Liver
;
: 624-631, 2016.
Article
in English
| WPRIM
| ID: wpr-164309
ABSTRACT
BACKGROUND/AIMS:
The diagnosis of spontaneous bacterial peritonitis (SBP) is based on a polymorphonuclear leukocytes (PMNs) exceeding 250/μL in ascitic fluid. The aim of the study was to evaluate serum procalcitonin and ascitic fluid calprotectin as accurate diagnostic markers for detecting SBP.METHODS:
Seventy-nine patients with cirrhotic ascites were included. They were divided into a SBP group, including 52 patients, and a non-SBP group of 27 patients. Serum procalcitonin, ascitic calprotectin, and serum and ascitic levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) were measured using an enzyme-linked immunosorbent assay.RESULTS:
Serum procalcitonin and ascitic calprotectin were significantly higher in SBP patients than in non-SBP patients. Significant increases in both serum and ascitic levels of TNF-α and IL-6 were observed in SBP patients versus non-SBP patients. At a cutoff value of 0.94 ng/mL, serum procalcitonin had 94.3% sensitivity and 91.8% specificity for detecting SBP. In addition, at a cutoff value of 445 ng/mL, ascitic calprotectin had 95.4% sensitivity and 85.2% specificity for detecting SBP. Both were positively correlated with ascitic fluid proteins, PMN count, TNF-α, and IL-6.CONCLUSIONS:
According to our findings, determination of serum procalcitonin levels and ascitic calprotectin appears to provide satisfactory diagnostic markers for the diagnosis of SBP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritonitis
/
Ascites
/
Ascitic Fluid
/
Enzyme-Linked Immunosorbent Assay
/
Sensitivity and Specificity
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Leukocyte L1 Antigen Complex
/
Diagnosis
/
Neutrophils
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS