Evaluation of Arterial Stiffness in Patients with Behcet's Disease by Using Noninvasive Radiological Methods such as Intima-Media Thickness of the Carotid, Ankle-Brachial Pressure Index, Coronary Artery Calcium Scoring, and Their Relation to Serum Fetuin-
Annals of Dermatology
;
: 702-708, 2015.
Article
in English
| WPRIM
| ID: wpr-164336
ABSTRACT
BACKGROUND:
Behcet's disease (BD) is a chronic, recurrent inflammatory systemic vasculitis. Evidence for increased atherosclerosis in BD has been observed. The relation between cardiovascular risk factors and increased atherosclerosis in patients with BD is still controversial.OBJECTIVE:
We performed this study to evaluate arterial stiffness in patients with BD by using noninvasive radiological methods such as carotid artery intima-media thickness (CIMT), ankle-brachial pressure index (ABPI), coronary artery calcium score (CACaS), and their relation to serum fetuin-A levels, which was recently found to be important in vascular calcification.METHODS:
This prospective study included 26 patients with BD and 25 control subjects. In all patients, the CIMT, ABPI, CACaS, and serum fetuin-A levels were examined.RESULTS:
The CIMT and CACaS were statistically higher and the ABPI was statistically lower in BD patients than in the control group. All p-values were <0.001. Positive correlations were found between the CACaS and CIMT, and negative correlations were found between the CACaS and ABPI. Although the values of fetuin-A were higher in BD, the difference was not statistically significant (p=0.064). However, the correlations found between fetuin-A levels and CIMT and between fetuin-A levels and CACaS were significant.CONCLUSION:
The CIMT, CACaS, and ABPI are all useful in detecting structural and functional vascular damage in BD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cardiovascular Diseases
/
Carotid Arteries
/
Case-Control Studies
/
Calcium
/
Prospective Studies
/
Risk Factors
/
Coronary Vessels
/
Atherosclerosis
/
Ankle Brachial Index
/
Systemic Vasculitis
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2015
Type:
Article
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