A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009) in a Patient with Acute Myeloid Leukemia / 감염과화학요법
Infection and Chemotherapy
;
: 107-111, 2010.
Article
in Korean
| WPRIM
| ID: wpr-164532
ABSTRACT
Oseltamivir is the drug of choice for patients with pandemic influenza (H1N1 2009). However, sporadic cases of oseltamivir resistance have been described worldwide. Up to March 2010, a total of 11 strains (2.2% of tested isolates) of oseltamivir-resistant pandemic influenza (H1N1 2009) have been discovered in South Korea. We report a case of 46-year-old man with acute myeloid leukemia in whom an oseltamivir-resistant pandemic (H1N1) 2009 virus was isolated. Despite high dose oseltamivir therapy for 10 days he had persistent symptoms and showed positive results in repeated real-time RT-PCR for pandemic influenza (H1N1 2009) virus from nasopharyngeal specimen. The patient improved eventually after oseltamivir was replaced by zanamivir inhalation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Viruses
/
Leukemia, Myeloid, Acute
/
Leukemia
/
Inhalation
/
Influenza, Human
/
Oseltamivir
/
Zanamivir
/
Republic of Korea
/
Pandemics
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Infection and Chemotherapy
Year:
2010
Type:
Article
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