Multiple myeloma and chronic myelogenous leukemia: a case report with literature review
Yonsei Medical Journal
; : 293-300, 1993.
Article
in En
| WPRIM
| ID: wpr-164588
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WPRO
ABSTRACT
This is the case of a 71 year old male who developed multiple myeloma (MM) and chronic myelogenous leukemia (CML) within a two year period. The patient initially presented with osteolytic lesions of the lumbar spine, and following the initial work-up a diagnosis of multiple myeloma with an IgG kappa paraproteinemia was made and appropriate treatment was given. Two years later the patient developed a progressively worsening leukocytosis which was found to be due to Philadelphia Chromosome (Ph1) positive CML. The occurrence in the same patient of two distinct hematologic malignancies suggests a neoplastic transformation of a pluripotent stem cell. A review of the literature appears to support the existence of a relationship between MM and CML as well as a relationship between MM and the myeloproliferative disorders.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Hematopoietic Stem Cells
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Cell Transformation, Neoplastic
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Multiple Myeloma
Limits:
Aged
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Humans
/
Male
Language:
En
Journal:
Yonsei Medical Journal
Year:
1993
Type:
Article