Neuroprotective Effect of Anthocyanin on Experimental Traumatic Spinal Cord Injury
Journal of Korean Neurosurgical Society
;
: 205-211, 2011.
Article
in English
| WPRIM
| ID: wpr-164804
ABSTRACT
OBJECTIVE:
We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats.METHODS:
The animals were divided into two groups the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-beta-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups.RESULTS:
At 14 days after SCI, the AT group showed significant improvement of the BBB score by 16.7+/-3.4%, platform hang by 40.0+/-9.1% and hind foot bar grab by 30.8+/-8.4% (p<0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group (0.98+/-0.38) than the control group (1.34+/-0.24) (p<0.05). The lesion volume in lesion periphery was 32.1+/-2.4 microL in the control and 24.5+/-2.3 microL in the AT group, respectively (p<0.05), and the motor neuron cell number of the anterior horn in lesion periphery was 8.3+/-5.1 cells/HPF in the control and 13.4+/-6.3 cells/HPF in the AT group, respectively (p<0.05).CONCLUSION:
Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Spinal Cord
/
Spinal Cord Injuries
/
Stomach
/
Cell Count
/
Administration, Oral
/
Superoxides
/
Neuroprotective Agents
/
Fluorescence
/
Foot
Limits:
Animals
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2011
Type:
Article
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