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Systemic Lupus Erythematosus Presenting as Stevens-Johnson Syndrome: A Case Report / 대한피부과학회지
Korean Journal of Dermatology ; : 293-296, 2017.
Article in Korean | WPRIM | ID: wpr-165087
ABSTRACT
Acute cutaneous lupus erythematosus (ACLE) on the face is a usual pattern of presentation. However, it can rarely present with a generalized distribution. A hyperacute form of ACLE can mimic Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN). A 33-year-old man presented with erythematous eroded papules and patches on his head, neck, and upper chest over 2 months. Moreover, he showed hemorrhagic crusted erosions on his lips, and buccal and nasal mucosa, in addition to conjunctival injection. A skin biopsy from his cheek showed a mild degree of vacuolar alteration, thickening of the basement membrane, perivascular and periadnexal lymphohistiocytic infiltration, and stromal mucin deposition. Direct immunofluorescence (DIF) demonstrated IgG and IgM deposits along the basement membrane zone. Laboratory investigations demonstrated pancytopenia, positive antinuclear antibody (ANA), anti-double stranded DNA (anti-dsDNA), and anti-Ro antibodies. The patient was diagnosed with systemic lupus erythematosus (SLE) based on clinical, histological, and laboratory markers of autoimmune disease. We report a rare case of SLE presenting as SJS.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancytopenia / Skin / Autoimmune Diseases / Thorax / Basement Membrane / Biopsy / Lupus Erythematosus, Cutaneous / DNA / Immunoglobulin G / Immunoglobulin M Limits: Adult / Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancytopenia / Skin / Autoimmune Diseases / Thorax / Basement Membrane / Biopsy / Lupus Erythematosus, Cutaneous / DNA / Immunoglobulin G / Immunoglobulin M Limits: Adult / Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2017 Type: Article