Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
Experimental Neurobiology
;
: 18-22, 2013.
Article
in English
| WPRIM
| ID: wpr-165486
ABSTRACT
The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mg.kg(-1)) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mg.kg(-1)) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Memantine
/
N-Methylaspartate
/
Haloperidol
/
Interpersonal Relations
/
Ketamine
/
Motor Activity
Limits:
Animals
Language:
English
Journal:
Experimental Neurobiology
Year:
2013
Type:
Article
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