A Case of Multiple Tuberculosis Associated with Infliximab Therapy in Crohn's Disease / 대한내과학회지
Korean Journal of Medicine
;
: 337-341, 2012.
Article
in Korean
| WPRIM
| ID: wpr-165635
ABSTRACT
Infliximab, a tumor necrosis factor-alpha (TNF-alpha) inhibitor, has been approved for the treatment of a variety of inflammatory illnesses, including Crohn's disease. However, infliximab can increase the risk of reactivation of latent tuberculosis (Tbc) infection by affecting host immune responses. Therefore, a screening test should be performed before the initiation of infliximab therapy, and patients with evidence of latent infection should be treated with prophylactic anti-Tbc therapy. Here, we report a case of multifocal disseminated tuberculosis after treatment with infliximab in a patient diagnosed with Crohn's disease who had no past history of Tbc and showed a negative screening test.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tuberculosis
/
Crohn Disease
/
Mass Screening
/
Tumor Necrosis Factor-alpha
/
Latent Tuberculosis
/
Infliximab
/
Antibodies, Monoclonal
Type of study:
Prognostic study
/
Screening study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2012
Type:
Article
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