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A study on the hemolytic properties of Prevotella nigrescens / 대한치과보존학회지
Journal of Korean Academy of Conservative Dentistry ; : 335-343, 2005.
Article in Korean | WPRIM | ID: wpr-16566
ABSTRACT
Hemolytic property is a specific feature of bacteria to obtain iron which is essential for its survival in host tissues. Therefore, it is thought to be one of several factors of virulence. The purpose of this study was to investigate the hemolytic properties of Prevotella nigrescens isolated from the teeth diagnosed as pulp necrosis and apical periodontitis under the presence of hemolysin inhibitors such as NaN3 and dithiothreitol, heat, various pH and cultural conditions. The results were as follows; 1. Clinically isolated P. nigrescens strains and standard P. nigrscens ATCC 33563 showed hemolytic activity. 2. P. nigrescens showed higher hemolytic activity against human erythrocytes than sheep or horse erythrocytes. 3. NaN3 and dithiothreitol (DTT) reduced the hemolytic activity of P. nigrescens in a dose dependent manner (p < 0.05). 4. Optimal pH for the maximum hemolytic activity of P. nigrescens was 4.0 and the hemolysin was stable under the 50degrees C, but the hemolytic activity was significantly decreased at 95degrees C. 5. P. nigrescens cultured in 10% CO2 condition showed higher hemolytic activity than the bacteria cultured in the anaerobic condition.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Periapical Periodontitis / Bacteria / Tooth / Virulence / Sheep / Prevotella / Dental Pulp Necrosis / Sodium Azide / Prevotella nigrescens / Dithiothreitol Limits: Humans Language: Korean Journal: Journal of Korean Academy of Conservative Dentistry Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Periapical Periodontitis / Bacteria / Tooth / Virulence / Sheep / Prevotella / Dental Pulp Necrosis / Sodium Azide / Prevotella nigrescens / Dithiothreitol Limits: Humans Language: Korean Journal: Journal of Korean Academy of Conservative Dentistry Year: 2005 Type: Article