Long-term outcomes of infantile spasms / 소아과
Korean Journal of Pediatrics
;
: 80-84, 2010.
Article
in English
| WPRIM
| ID: wpr-165727
ABSTRACT
PURPOSE:
The aims of this study were to investigate the long-term outcomes in children with infantile spasms (IS) and to identify the prognostic factors influencing their neurodevelopment.METHODS:
We retrospectively evaluated seventy two children over five years old who were treated for IS at Asan Medical Center, Seoul, Korea, between 1994 and 2007. Forty-three children were contacted by telephone or medical follow-up to assess their current neurodevelopmental status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence interval (95% CIs) of risk factors for unfavorable outcomes.RESULTS:
The mean follow-up duration for these 43 children was 7.2+/-1.5 years (range, 4.5 to 13.0 years). Of these, 13 (30.2%) had cryptogenic and 30 (69.8%) had symptomatic IS. Eleven (25.6%) children were initially treated with adrenocorticotrophic hormone (ACTH) therapy, with a mean treatment lag of 1.3+/-1.9 months (range; 0.1 to 7.0 months). Eighteen (41.8%) children clinically responded to initial treatment, as shown by EEG response. Overall, 22 (51.2%) children had at least moderate neurodevelopmental disorders and 2 (4.8%) died. In univariate analysis, etiology (symptomatic) and poor electroclinical response to initial treatment were related to long-term unfavorable outcomes. In multivariate analysis, response to primary treatment was the sole significant independent risk factor with a high OR.CONCLUSION:
Overall prognosis of children with IS was poor. Electroclinical non-responsiveness to initial treatment was related to unfavorable long-term outcomes, indicating that initial control of seizures may be important in reducing the likelihood of poor neurodevelopment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Seizures
/
Spasms, Infantile
/
Telephone
/
Logistic Models
/
Odds Ratio
/
Multivariate Analysis
/
Retrospective Studies
/
Risk Factors
/
Follow-Up Studies
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
/
Infant
/
Infant, Newborn
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2010
Type:
Article
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