The role of scheduled second TACE in early-stage hepatocellular carcinoma with complete response to initial TACE
Clinical and Molecular Hepatology
;
: 42-50, 2017.
Article
in English
| WPRIM
| ID: wpr-165810
ABSTRACT
BACKGROUND/AIMS:
We investigated the outcomes of early-stage hepatocellular carcinoma (HCC) patients who showed a complete response (CR) to initial transarterial chemoembolization (TACE), with a focus on the role of scheduled TACE repetition.METHODS:
A total of 178 patients with early-stage HCC who were initially treated with TACE and showed a CR based on the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria on one month follow-up computed tomography (CT) were analyzed. Among them, 90 patients underwent scheduled repetition of TACE in the absence of viable tumor on CT.RESULTS:
During a median follow-up period of 4.6 years (range 0.4-8.8 years), mortality was observed in 71 patients (39.9%). The overall recurrence-free and local recurrence-free survival rates at 1 year were 44.4% and 56.2%. In the multivariable model, scheduled repetition of TACE was an independent factor associated with survival (hazard ratio [95% confidence interval] 0.56 [0.34-0.93], P=0.025). When stratified using Barcelona clinic liver cancer (BCLC) stage, scheduled repetition of TACE was associated with a favorable survival rate in BCLC stage A patients, but not in BCLC 0 patients.CONCLUSIONS:
Scheduled repetition of TACE was associated with better survival for early-stage HCC patients showing a CR after initial TACE, especially in BCLC stage A patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Survival Rate
/
Follow-Up Studies
/
Mortality
/
Carcinoma, Hepatocellular
/
Response Evaluation Criteria in Solid Tumors
/
Liver Neoplasms
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clinical and Molecular Hepatology
Year:
2017
Type:
Article
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