Dermatophagoides Pteronyssinus Specific IgG-subclass Antibodies in Allergic Children

ABSTRACT

PURPOSE: Although immunoglobulin E play a major role in immediate hypersensitivity reactions, some reaginic activity is associated with IgG. Part of the reaginic activity is associated with IgG1, IgG4. In contrast with this reaginic activity of IgG4, allergen-specific IgG4 antibody is allergen neutralizing antibody and contribute to the benificial effect of immunotherapy. The role of specific IgG antibody in allergic disorder is uncertain. The Dermatophagoides pteronyssinus is well known as the major allergen triggering allergic disorder. For determining the distribution of specific IgE and IgG subclass antibodies and their role in allergic disorders. Mehtods Specific IgE and IgG subclasses to Dermatophagoides pteronyssinus (Dp) were measured in 62 allergic children (Group I;Bronchial asthma, Group II; Bronchial asthma +Allergic rhintis) aged 8-13 year. All of them had positive skin test to Dp and every data were compared with thet of 42 normal control. RESULTS: 1) Dp specific IgE antibody titer was significantly higher in Group I, II, III than in control group (p< .01). 2) pecific IgG, IgG1, IgG2, IgG4 antibodies were higher in all three allergic groups than in control group (p< .01). 3) Specific IgG, IgG1, IgG2, IgG3, IgG4 antibodies were higher in patient with asthma and allergic thinitis than asthma or allergic rhnitis. 4) The linear correlation between specific IgE and IgG, IgG1 or IgG4 was not significant (p< 0.05). CONCLUSIONS: Specific IgE, IgG and IgG subclass antibodies were increased in allergic disorders than normal control. The level of specific IgG and IgG subclass antibodies were higher as the clinical symptoms were more severe.