Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
Biomolecules & Therapeutics
;
: 4-11, 2017.
Article
in English
| WPRIM
| ID: wpr-165942
ABSTRACT
Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the β2-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
GTP-Binding Proteins
/
Heterotrimeric GTP-Binding Proteins
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS