Fatal Infectious Mononucleosis: A case report / 대한법의학회지
Korean Journal of Legal Medicine
;
: 188-191, 2007.
Article
in Korean
| WPRIM
| ID: wpr-165976
ABSTRACT
Infectious mononucleosis(IM) is a benign self-limiting disease and result from a polyclonal B cell proliferation secondary to Epstein-Barr virus (EBV) infections. The infection is controlled by cytotoxic T cells triggered by EBV infected B cells. However, rare cases develop severe or fatal IM accompanied by hemophagocytic syndrome. We report a case of a 4-year-old girl who presented with high fever, hepatosplenomegaly, hepatic failure, pancytopenia and coagulopathy. Despite intensive treatment, the patient's condition deteriorated rapidly and died 3 days after admission. At autopsy, there was prominent infiltration of atypical lymphocytes with hemophagocytosis in multiple organs, especially liver, spleen and lymph nodes. Atypical lymphocytes were immunopositive for T cell markers and showed positive signal in EBV in situ hybridization.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancytopenia
/
Autopsy
/
Spleen
/
B-Lymphocytes
/
Lymphocytes
/
T-Lymphocytes
/
Liver Failure
/
In Situ Hybridization
/
Herpesvirus 4, Human
/
Cell Proliferation
Limits:
Child, preschool
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Legal Medicine
Year:
2007
Type:
Article
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