Dexamethasone alone versus in combination with intra-operative super-hydration for postoperative nausea and vomiting prophylaxis in female patients undergoing laparoscopic cholecystectomy: a randomized clinical trial / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 535-541, 2017.
Article
in English
| WPRIM
| ID: wpr-166100
ABSTRACT
BACKGROUND:
Dexamethasone has a prophylactic effect on postoperative nausea and vomiting (PONV) and perioperative hydration is believed to play a role in PONV prophylaxis. This study was performed to examine the combined effects of pre-induction dexamethasone plus super-hydration on PONV and pain following laparoscopic cholecystectomy (LC).METHODS:
A total of 100 female patients undergoing LC were enrolled and randomized equally into two groups. Group DF received 5 mg dexamethasone (pre-induction) plus 30 ml/kg Ringer's lactate (intraoperative) and group D received 5 mg dexamethasone (pre-induction) alone. Anesthetic and surgical managements were standardized for all patients. The incidence and severity of PONV, and intra and post-operative analgesic and postoperative antiemetic consumption, were assessed during the first 24 h postoperatively. Post-anesthesia care unit (PACU) stay and aggregated 24 h pain scores were calculated.RESULTS:
Group DF had significantly lower PONV than group D (P = 0.03). The number of patients with the lowest PONV score was significantly increased in group DF (P = 0.03). Ondansetron consumption was significantly lower in group DF (P < 0.0001). The mean accumulated 24 h pain scores were significantly lower in group DF compared to group D (P < 0.0001). The time to first analgesic request was significantly longer in group DF than group D (P < 0.0001). In addition, total meperidine consumption during the first postoperative 24 h was significantly lower in group DF than group D (P = 0.002).CONCLUSIONS:
In female patients undergoing LC, pre-induction with 5 mg dexamethasone plus intraoperative 30 ml/kg Ringer's lactate solution decreased PONV and pain during the first 24 h postoperatively compared to 5 mg dexamethasone alone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dexamethasone
/
Cholecystectomy
/
Incidence
/
Ondansetron
/
Cholecystectomy, Laparoscopic
/
Laparoscopy
/
Lactic Acid
/
Postoperative Nausea and Vomiting
/
Meperidine
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2017
Type:
Article
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