Additive Estrogenic Activities of the Binary Mixtures of Four Estrogenic Chemicals in Recombinant Yeast Expressing Human Estrogen Receptor
Journal of Veterinary Science
;
: 1-5, 2002.
Article
in English
| WPRIM
| ID: wpr-16611
ABSTRACT
To evaluate the estrogenic activities of several chemicals such as 17 beta-estradiol (E2), rho-nonylphenol, bisphenol A, butylparaben, and combinations of these chemicals, we used recombinant yeasts containing the human estrogen receptor [Saccharomyces cerevisiae ER + LYS 8127]. We evaluated E2 was most active in the recombinant yeast assay, followed by rho-nonylphenol, bisphenol A, butylparaben. The combinations of some concentrations of 17-estradiol as a strong estrogen and bisphenol A or butylparaben as a weak estrogen showed additive estrogenic effects. Also, the combinations of some concentrations of nonlyphenol and butylparaben and combination of butylparaben and bisphenol A showed additive effects in the estrogenic activity. Therefore, the estrogenic activities of the combinations of two chemicals were additive, not synergistic.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parabens
/
Phenols
/
Saccharomyces cerevisiae
/
Recombinant Proteins
/
Kinetics
/
Receptors, Estrogen
/
Cloning, Molecular
/
Estradiol
/
Estrogens
/
Estrogens, Non-Steroidal
Limits:
Humans
Language:
English
Journal:
Journal of Veterinary Science
Year:
2002
Type:
Article
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