Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: 168-173, 2013.
Article
in English
| WPRIM
| ID: wpr-166294
ABSTRACT
PURPOSE:
Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH.METHODS:
A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed.RESULTS:
The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05).CONCLUSION:
We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Prostate-Specific Antigen
/
Disease Progression
/
Polymorphism, Single Nucleotide
/
Aldehyde Dehydrogenase
/
Gene Frequency
/
Genotype
/
Hyperplasia
/
Metabolism
Limits:
Humans
Language:
English
Journal:
International Neurourology Journal
Year:
2013
Type:
Article
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