Resurgence of Poststreptococcal Acute Glomerulonephritis in Chinju: Clinical Review of Recent 10 Years / 감염

ABSTRACT

BACKGROUND: Rheumatic fever(RF) or streptococcal invasive diseases have surged in developed countries recently. Incidence of poststreptococcal acute glomerulonephritis (PSAGN), a sequelae of group A streptococci (GAS) infection was investigated to evaluate the resurgence of PSAGN in Chinju. METHODS: Medical records of 90 patients with PSAGN from January 1988 were reviewed retrospectively. Annual incidence, clinical characteristics, and laboratory findings were analyzed. RESULTS: Annual incidence of PSAGN decreased until 1993, to as low as 0.09%, but started to increase in 1994 and became significantly high (1.83%) in 1996 (P<0.01). Most (64.6%) of PSAGN cases occurred from October to January. Major symtoms were edema (78.9%), gross hematuria (65.6%), oligura (22.2%), an fever (16.7%). Hypertension was observed in 28.9% during admission. Increse of ASO were observed in 92.0% (80/87), decrease of C3 and CH50 in 94.4% (85/90) and 93.2% (41/44), respectively. CONCLUSION: Annual incidence of PSAGN decreased until 1993, but increased from 1994. Whether this resurgence of PSAGN is merely regional or part of a national epidemic should be investigated.