Elevated Calcium after Acute Ischemic Stroke: Association with a Poor Short-Term Outcome and Long-Term Mortality / 대한뇌졸중학회지
Journal of Stroke
;
: 54-59, 2015.
Article
in English
| WPRIM
| ID: wpr-166387
ABSTRACT
BACKGROUND AND PURPOSE:
An elevated intracellular calcium level is known to be a major initiator and activator of ischemic cell death pathway; however, in recent studies, elevated serum calcium levels have been associated with better clinical outcomes and smaller cerebral infarct volumes. The pathophysiological role played by calcium in ischemic stroke is largely unknown.METHODS:
Acute stroke patients from a prospective stroke registry, consecutively admitted during October 2002-September 2008, were included. Significant associations between the modified Rankin scale distribution at discharge and serum calcium or albumin-corrected calcium were identified using ordinal logistic regression analysis. Cox proportional hazard models were used for survival analysis.RESULTS:
Mean serum calcium and albumin-corrected calcium levels of the 1,915 participants on admission were 8.97+/-0.58 mg/dL and 9.07+/-0.49 mg/dL, respectively. Second [adjusted odds ratio 1.32 (95% confidence interval 1.07-1.61)] and third [1.24 (1.01-1.53)] tertiles of serum calcium level and the third [1.24 (1.01-1.53)] tertile of albumin-corrected calcium level were found to be independent risk factors for a poor discharge outcome. Significant relationships were observed with serum calcium [1.19 (1.03-1.38)] and albumin-corrected calcium [1.21(1.01-1.44)] as linear variables. However, only albumin-corrected calcium was associated with long-term mortality, third tertile [adjusted hazard ratio 1.40 (1.07-1.83)], and increase by 1 mg/dL [1.46 (1.16-1.84)].CONCLUSIONS:
Elevated albumin-corrected serum calcium levels are associated with a poorer short-term outcome and greater risk of long-term mortality after acute ischemic stroke.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Logistic Models
/
Odds Ratio
/
Proportional Hazards Models
/
Cerebral Infarction
/
Calcium
/
Prospective Studies
/
Risk Factors
/
Mortality
/
Cell Death
/
Stroke
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Stroke
Year:
2015
Type:
Article
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