The Effect of Human Albumin Infusion on the Clinical Course of Steroid Sensitive Nephrotic Syndrome
Journal of the Korean Society of Pediatric Nephrology
;
: 102-110, 2000.
Article
in Korean
| WPRIM
| ID: wpr-167560
ABSTRACT
PURPOSE:
Intravenous infusion of albumin has been widely used to relieve severe nephrotic edema in spite of beneficial or harmful effects. The purpose of this study is to examine the harmful effect of albumin on the clinical course of steroid sensitive nephrotic syndrome(SSNS).METHOD:
We prospectively randomized the patients with nephrotic syndrome(biopsy proven or clinically compatible to minimal change nephrotic syndrome) into the albumin group(20% albumin 1 g/kg) or control group(5% D/W) between March 1997 and September 1999 at Ewha University Mokdong Hospital. We compared the clinical course of the albumin group(n=13) with the control group(n=13).RESULTS:
1. The duration of steroid therapy until complete remission in the albumin group was significantly longer than the control group(13.7+/-6.4 days vs 7.5+/-2.8 days)(P0.05) and the relapse frequency per year(1.9+/-0.8 vs 1.5+/-0.5) between the albumin and control groups. 3. Spot urine protein/creatinine ratio significantly increased in the albumin group at post-albumin 2, 4 days(P<0.05). There was no significant difference in the change of the daily percent weight loss, blood pressure, serum Na, K concentration between the albumin and control groups.CONCLUSION:
Albumin infusion in SSNS delayed the response to steroid and shortened the remission duration to the first relapse. Albumin should be carefully used in nephrotic edema.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Blood Pressure
/
Infusions, Intravenous
/
Weight Loss
/
Prospective Studies
/
Edema
/
Nephrotic Syndrome
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Pediatric Nephrology
Year:
2000
Type:
Article
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