Effect of ApoE Genotype on the Relationship between Nutritional Risk and Cognition in the Elderly
Journal of the Korean Geriatrics Society
;
: 177-185, 2006.
Article
in Korean
| WPRIM
| ID: wpr-167575
ABSTRACT
BACKGROUND:
The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community.METHODS:
A total of 996 subjects (343 men and 653 women) aged 60~91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping.RESULTS:
649 subjects (65.2%) were on good nutritional state (NSI score or = 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score < or = 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE epsilon4 allele (OR 1.78, 95% CI 1.15-2.77).CONCLUSION:
These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE epsilon4 allele.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins E
/
Blood Glucose
/
Blood Pressure
/
Body Mass Index
/
Logistic Models
/
Mass Screening
/
Surveys and Questionnaires
/
Fasting
/
Cognition
/
Dementia
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Aged
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Geriatrics Society
Year:
2006
Type:
Article
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