1828G > A polymorphism of the UDP-glucuronosyltransferase gene (UGT1A1) for neonatal hyperbilirubinemia in Koreans / 소아과
Korean Journal of Pediatrics
;
: 34-39, 2006.
Article
in Korean
| WPRIM
| ID: wpr-167858
ABSTRACT
PURPOSE:
The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in Caucasians. However, its metabolic basis has not been clearly explained. The UDP-glucuronosyltransferase gene(UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia. We studied whether neonatal hyperbilirubinemia is associated with the 1828G>A(rs 10929303) polymorphism of the UGT1A1 gene, which encodes for a key enzyme of bilirubin metabolism.METHODS:
The genomic DNA was isolated from 80 Korean full term neonates who had greater than a 12 mg/dL level of serum bilirubin with no obvious cause, and the genomic DNA was also isolated from 164 Korean neonates of the control population. We studied a single nucleotide polymorphism (SNP) of 1828G>A in the untranslated region of the UGT1A1 gene by direct sequencing.RESULTS:
Three of the 80 neonates with a serum bilirubin level above 12 mg/dL had homozygous mutations and 10 of the 80 neonates with a serum bilirubin level above 12 mg/dL had heterozygous mutations. Thirteen of the 164 neonates of the control group had homozygous mutations and 16 neonates of the control group had heterozygous mutations. The allele frequency of 1828G>A polymorphism of UGT1A1 in the hyperbilirubinemia group was 10.0 percent, which was not significantly different from the allele frequency of 12.8 percent in the control group.CONCLUSION:
In this study, the 1828G>A polymorphism of the UGT1A1 gene was detected in the Korean neonates with neonatal hyperbilirubinemia. Our results indicated that this SNP is not associated with the prevalence of hyperbilirubinemia in Koreans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bilirubin
/
DNA
/
Incidence
/
Prevalence
/
Risk Factors
/
Untranslated Regions
/
Polymorphism, Single Nucleotide
/
Asian People
/
Hyperbilirubinemia, Neonatal
/
Gene Frequency
Type of study:
Etiology study
/
Incidence study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2006
Type:
Article
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