A Case of Baclofen-Induced Encephalopathy in a Patient with ESRD on Continuous Ambulatory Peritoneal Dialysis / 대한신장학회지
Korean Journal of Nephrology
;
: 211-214, 2011.
Article
in Korean
| WPRIM
| ID: wpr-167970
ABSTRACT
Baclofen (beta-4-chlorophenyl-gamma-aminobutyric acid), a gamma-aminobutyric acid (GABA) derivative, is commonly used for relief of spinal-origin spasm or pain. Baclofen is eliminated predominantly by the kidneys, putting patients with impaired renal function at particular risk for baclofen accumulation. The authors report on a case of baclofen-induced encephalopathy in a patient on continuous ambulatory peritoneal dialysis (CAPD). A 56 year old patient with ESRD on CAPD was admitted due to stuporous mental status after baclofen treatment. Brain imaging showed no specific abnormality. After intensive treatment of CAPD for 3 days, neurologic abnormality was completely recovered. Baclofen should not be recommended for patients with renal dysfunction. Although the best-known treatment choice for baclofen toxicity is hemodialysis, intensive CAPD can also be considered as an option for treatment of baclofen toxicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spasm
/
Baclofen
/
Renal Dialysis
/
Peritoneal Dialysis, Continuous Ambulatory
/
Stupor
/
Neuroimaging
/
Gamma-Aminobutyric Acid
/
Kidney
/
Kidney Failure, Chronic
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2011
Type:
Article
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