Clinical Significance of Anti-topoisomerase I Antibodies Detected by Enzyme Linked Immunosorbent Assay / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 47-51, 2002.
Article
in Korean
| WPRIM
| ID: wpr-167988
ABSTRACT
BACKGROUND:
Anti-topoisomerase I antibodies (anti-topo-I) have been known to be a specific serologic marker for systemic sclerosis (SSc). However, anti-topo-I have also been detected fre-quently in the sera of patients with diagnosis other than SSc since the enzyme linked immunosor-bent assay (ELISA) has been used widely. In order to clarify the clinical significance of anti-topo-I on ELISA, we analyzed the clinical features of the patients positive for anti-topo-I.METHODS:
Anti-topo-I and other antinuclear antibodies (ANA) were investigated by conventional ELISA methods. The clinical characteristics were analyzed in 38 patients positive for anti-topo-I and 28 patients with SLE but negative for anti-topo-I.RESULTS:
Of 38 patients positive for anti-topo-I, 15 were SLE and eight SSc. The mean level of anti-topo-I in the patients with SSc was higher than that in the patients with SLE (P=0.015). Of 15 anti-topo-I positive patients with SLE, 14 had one or more other ANAs in their sera whereas only one of eight anti-topo-I positive patients with SSc did (P=0.000). There was no significant difference in clinical characteristics between anti-topo-I positive and negative patients with SLE. The preva-lences of restrictive lung disease in both groups with SLE were significantly lower than that in the anti-topo-I positive patients with SSc (P=0.008).CONCLUSIONS:
Anti-topo-I is not exclusively specific for SSc and present in a considerable subset of SLE. As well as the level of anti-topo-I, the coexistence of other ANAs is helpful to discriminate SLE from SSc. The Anti-topo-I detected by ELISA does not seem to be a risk factor for restrictive lung disease in the patients with SLE, unlike those with SSc.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Scleroderma, Systemic
/
Enzyme-Linked Immunosorbent Assay
/
Antibodies, Antinuclear
/
Risk Factors
/
Diagnosis
/
Lung Diseases
/
Antibodies
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Clinical Pathology
Year:
2002
Type:
Article
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