Modulatory Effect of Ammonium Carbonate on the GABAA Receptor
Journal of the Korean Child Neurology Society
;
: 39-46, 1998.
Article
in Korean
| WPRIM
| ID: wpr-16810
ABSTRACT
PURPOSE:
This study was aimed to investigate the modulatory effect of ammonium carbonate on the GABAA receptor.METHODS:
The effects of ammonium carbonate on the binding of radioligands to components of the GABAA receptor complex were observed.RESULTS:
[3H]Flunitrazepam binding to the benzodiazepine receptor was enhanced by ammonium (1mM) ammonia concentrations. This increase in GABAergic neurotransmission is consistent with the clinical picture of lethargy, ataxia and cognitive deficits associated with liver failure and congenital hyperammonemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ataxia
/
Carbon
/
Liver Failure
/
Receptors, GABA
/
Receptors, GABA-A
/
Synaptic Transmission
/
Hyperammonemia
/
Lethargy
/
Ammonium Compounds
/
Gamma-Aminobutyric Acid
Language:
Korean
Journal:
Journal of the Korean Child Neurology Society
Year:
1998
Type:
Article
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